Besides the APOE locus, novel associations with two other well-established AD risk loci were observed CR1 was shown a locus for Aβ42 and BIN1 for pTau. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total of 13,116 individuals (discovery n = 8074 replication n = 5042 individuals).
Wiesje van der Flier ORCID: /0000-0001-8766-6224 1, 2 na2Īcta Neuropathologica volume 144, pages 821–842 ( 2022) Cite this articleĪmyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer’s disease (AD) more directly than clinical diagnosis.Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers
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